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In clinical pharmacology studies, tadalafil was shown to potentiate the hypotensive effect of nitrates [see Clinical Pharmacology Hypersensitivity reactions have been reported, including Stevens-Johnson syndrome and exfoliative tablets [see Adverse Reactions 6. Do medical use tadalafil in patients who are using a GC stimulator, such as riociguat. PDE5 inhibitors, including tadalafil, may potentiate the hypotensive effects of GC stimulators.

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